Pathological Diagnosis of Thyroid Nodules with Preoperatively Detected TERT Promoter Mutations in the Absence of BRAF V600E : A Bi-Center Series of 52 Cases
Authors' conclusion
Thirty five percent of TERTp nodules without BRAFV600E are benign/low-risk thyroid neoplasms, leading to their overtreatment. The incidence of high-risk carcinomas increases in TERTp-mutated nodules with the presence of additional mutations.
Study context
- Population
- Thyroid nodules with TERTp mutations without coexisting BRAFV600E on preoperative FNA ThyroSeq genomic classifier (GC), two academic medical centersfrom 2323 tested
- Participants
- 52 participants
- Exposure
- Molecular subgroups of TERTp-mutated nodules without BRAFV600E
- TERTp alonen = 21reference
- TERTp + RASn = 18
- TERTp + other non-RAS mutationn = 8
- TERTp + RAS + other alterationsn = 5
- Outcome
- Risk of malignancy (ROM) and surgical diagnosis
Methodological detailsbi-center
- Bi-center
Main finding
As reported in the abstract
ROM
- Overall risk of malignancy (ROM)
- 65%
- Benign/low-risk neoplasms
- 18 (35%)
- Carcinoma-ATA low/intermediate-risk
- 14 (27%)
- Carcinoma-ATA high-risk
- 20 (38.5%)
Observational data: associations, not effects.
Further findings
| Outcome | TERTp alone | TERTp + RAS | TERTp + RAS + other alterations | P value |
|---|---|---|---|---|
| ROM by molecular subgroup | — not stated in the abstract | 78% | 80% | |
| High-risk carcinomas: TERTp + other concomitant alterations vs TERTp alone | 9.5% | — not stated in the abstract | — not stated in the abstract | P = 0.006 |
— not stated in the abstract
- High-risk carcinomas: TERTp + other concomitant alterations vs TERTp alone: TERTp + other concomitant alterations 48%
- High-risk carcinomas: TERTp + other concomitant alterations vs TERTp alone: significantly higher with TERTp + other concomitant alterations
Original publication
Pathological Diagnosis of Thyroid Nodules with Preoperatively Detected TERT Promoter Mutations in the Absence of BRAF V600E : A Bi-Center Series of 52 Cases. Thyroid. Published 28 July 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →