Uric Acid Is Not Associated With Cardiovascular Health in Youth With Type 1 Diabetes: SEARCH for Diabetes in Youth Study
Authors' conclusion
Among adolescents and young adults with type 1 diabetes, uric acid was not consistently associated with increased BP or arterial stiffness over time. These results support findings from clinical trials in older adults with diabetes showing that lowering uric acid levels does not improve cardiovascular outcomes.
Study context
- Population
- Adolescents and young adults with T1D, SEARCH for Diabetes in Youth study, 2007–2018; mean age 17.6 years, 49.4% female, 75.9% non-Hispanic White45.4% had follow-up visit
- Participants
- 1,744 adolescents
- Exposure
- Uric acid at first visit and change in blood pressure (BP) and arterial stiffness
- Outcome
- Change in BP, pulse wave velocity (PWV) and augmentation index between visits
- Follow-up
- Mean 4.6 years
Methodological detailsmulticenter, longitudinal analysis, multivariable linear mixed-effects models
- Multicenter
- Longitudinal analysis
- Multivariable linear mixed-effects models
Main finding
As reported in the abstract
Association of uric acid with change in BP, PWV and augmentation index
Mean uric acid (SD 1.0)
3.7 mg/dL
Uric acid marginally associated with pulse wave velocity (PWV)-upper extremity, β (95% CI 0.002 to 0.04)
.02 m/s/year
Observational data: associations, not effects.
Further findings
Effect modification by overweight/obesity
- Magnitude of association did not differ by overweight/obesity status
Original publication
Uric Acid Is Not Associated With Cardiovascular Health in Youth With Type 1 Diabetes: SEARCH for Diabetes in Youth Study. J Clin Endocrinol Metab. Published 10 September 2023. doi:10.
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