Endogenous estradiol contributes to vascular endothelial dysfunction in premenopausal women with type 1 diabetes
Authors' conclusion
Endogenous estradiol increases oxidative stress and contributes to endothelial dysfunction in women with diabetes. Additionally, HBC use appears to be beneficial to endothelial function in type 1 diabetes.
Study context
- Population
- Premenopausal women with T1D and apparently healthy women; Flow-mediated dilation (FMD) during menses (M) and late follicular (LF) phase
- Participants
- 32 / 25 / 9 / 9
- Comparison
- Women with T1D vs healthy women, menses vs late follicular phase
- T1Dn = 32
- Controlsn = 25reference
- Hormonal birth control (HBC)n = 9
- No HBCn = 9reference
- Outcome
- Endothelial function by flow-mediated dilation (FMD)
- Follow-up
- Menses and late follicular phase
Main finding
As reported in the abstract
FMD
- FMD increased from M to LF phase in controls
- p = 0.024
Further findings
| Outcome | T1D | Controls |
|---|---|---|
| Change in estradiol, M to LF phase | 75 ± 86 pg/mL | 71 ± 76 pg/mL |
| Change in TBARS, M to LF phase | 3 ± 13 µM | 0 ± 4 µM |
Change in estradiol, M to LF phase
- Estradiol significantly increased during LF vs M in both groups
Change in thiobarbituric acid reactive substances (TBARS), M to LF phase
- Increase in TBARS only in T1D
Original publication
Endogenous estradiol contributes to vascular endothelial dysfunction in premenopausal women with type 1 diabetes. Cardiovasc Diabetol. Published 7 September 2023. doi:10.
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