Thyroid Hormone Levels Correlate With the Maturation of Implanted Pancreatic Endoderm Cells in Patients With Type 1 Diabetes
Authors' conclusion
These data highlight the relevance of thyroid hormones in the context of PEC therapy in patients with type 1 diabetes and suggest that a thyroid hormone adjuvant therapy may optimize cell outcomes in some PEC recipients.
Study context
- Population
- Patients with T1D implanted with macroencapsulated pancreatic endoderm cells (PECs), treated at 1 of the 7 sites of an ongoing clinical trial
- Outcome
- Association of thyroid hormone levels with PEC cell fate and glucagon
Methodological detailssingle site of a 7-site ongoing clinical trial, mouse experiments
- Single site of a 7-site ongoing clinical trial
- Mouse experiments
Main finding
As reported in the abstract
- Triiodothyronine and thyroxine levels significantly associated with the proportion of cells adopting an insulin-producing fate with a mature phenotype
- Thyroid hormone levels inversely correlated to circulating glucagon levels after implantation
Further findings
PEC maturation in hyperthyroid mice
- In mice, hyperthyroidism led to more rapid maturation of PECs into insulin-producing cells similar in phenotype to PECs in euthyroid mice
Original publication
Thyroid Hormone Levels Correlate With the Maturation of Implanted Pancreatic Endoderm Cells in Patients With Type 1 Diabetes. J Clin Endocrinol Metab. Published 6 September 2023. doi:10.
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