Interactive online calculator for estimation of muscle and hepatic insulin sensitivity in adults with Type 1 diabetes using clinical and research biomarkers
Authors' conclusion
We demonstrate that clinical and research biomarkers can be used to estimate tissue specific insulin sensitivity in adults with Type 1 diabetes.
Study context
- Population
- Adults with T1D participating in the INTIMET trial, characterised with 33 baseline biomarkers
- Participants
- 40 adults
- Comparison
- GIR formula vs EGP formula
- Outcome
- Prediction of unfavourable muscle (GIR) and hepatic (EGP) insulin sensitivity
Methodological detailstwo-step euglycaemic clamps with stable-isotope glucose, exhaustive search analyses, Free online tool converts these variables into dichotomised EGP and GIR estimates
- Two-step euglycaemic clamps with stable-isotope glucose
- Exhaustive search analyses
- Free online tool converts these variables into dichotomised EGP and GIR estimates
Performance
As reported in the abstract
| Test or model | AUROC | P | R2 (Nagelkerke) | Accuracy |
|---|---|---|---|---|
| GIR formula | 0.97 | p < 0.0001 | 0.83 | 92.5% |
| EGP formula | 0.86 | p = 0.001 | 0.50 | 80% |
AUROC
GIR formula0.97
EGP formula0.86
P
GIR formulap < 0.0001
EGP formulap = 0.001
R2 (Nagelkerke)
GIR formula0.83
EGP formula0.50
Accuracy
GIR formula92.5%
EGP formula80%
Original publication
Interactive online calculator for estimation of muscle and hepatic insulin sensitivity in adults with Type 1 diabetes using clinical and research biomarkers. Diabetes Obes Metab. Published 2 February 2026. doi:10.
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