Impact of screening programmes for type 1 diabetes in youth: A systematic review and meta‐analysis
Authors' conclusion
Population screening with IAbs and follow-up of IAb+ individuals helps decrease DKA and allows participation in intervention trials. This systematic review provides evidence for clinical practice on the screening timing, modalities and follow-up. Further studies on the use of CGM are expected.
Study context
- Population
- Children and adolescents (general population and first-degree relatives (FDRs)/high-risk individuals); searches 15 March 2006 to 15 March 202566 studies
- Comparison
- IAb screening vs no screening
- Outcome
- DKA risk at T1D onset (meta-analysis)
- Follow-up
- T1D onset
Methodological detailsGRADE quality assessment, PICOS framework, 53 of 66 studies of moderate-to-high quality
- GRADE quality assessment
- PICOS framework
- 53 of 66 studies of moderate-to-high quality
Pooled result
As reported in the abstract
DKA at T1D onset
Screening was associated with lower DKA rates by
23%
95% CI 18–29%, I2 = 88.8%
Further pooled results
Stage 3 T1D progression
- Risk high in younger children with persistent and/or multiple IAb+
Parental anxiety
- Screening associated with higher parental anxiety indicators, decreasing during follow-up
Follow-up modalities
- IAb+ children monitored by age and T1D stage using HbA1c, OGTT and continuous glucose monitoring (CGM); time above 140 mg/dL a biomarker of progression
Original publication
Impact of screening programmes for type 1 diabetes in youth: A systematic review and meta‐analysis. Diabet Med. Published 31 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →