The Risk of Disease Progression of Type 1 Diabetes in First‐Degree Relatives of People With Type 1 Diabetes: Design and Rationale of a Prospective, Longitudinal Study in China
Study context
- Population
- First-degree relatives (FDRs) of people with T1D in China, screened for islet autoantibodies (IAb); IAb-positive individuals monitoredplanned enrolment
- Participants
- 5,500 relatives
- Primary endpoint
- Risk of Stage 3 T1D onset in IAb-positive individuals
- Follow-up
- Up to 5 years
Methodological detailsmulticentre (≈50 hospitals in China), Single IAb-positive: HbA1c and IAb every year; multiple IAb-positive: HbA1c and oral glucose tolerance test (OGTT) every year (Stage 1 T1D), or OGTT or random blood glucose in alternate 6-monthly intervals and HbA1c every 3 months (Stage 2 T1D), Participants developing Stage 3 T1D can undergo extended follow-up of β-cell function, glycaemic outcomes and IAb status during the first 12 months after diagnosis
- Multicentre (≈50 hospitals in China)
- Single IAb-positive: HbA1c and IAb every year; multiple IAb-positive: HbA1c and OGTT every year (Stage 1 T1D), or OGTT or random blood glucose in alternate 6-monthly intervals and HbA1c every 3 months (Stage 2 T1D)
- Participants developing Stage 3 T1D can undergo extended follow-up of β-cell function, glycaemic outcomes and IAb status during the first 12 months after diagnosis
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
The Risk of Disease Progression of Type 1 Diabetes in First‐Degree Relatives of People With Type 1 Diabetes: Design and Rationale of a Prospective, Longitudinal Study in China. Diabetes Obes Metab. Published 30 March 2026. doi:10.
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