Adrenaline is a prominent driver of inflammatory responses following hypoglycaemia
Authors' conclusion
Levels of adrenaline similar to those seen in response to hypoglycaemia elicit an acute and prolonged inflammatory response in people with type 1 diabetes and matched control participants on a cellular, functional and protein level. These findings suggest that adrenaline is a prominent driver of inflammatory responses following hypoglycaemia.
Study context
- Population
- Adults with T1D and matched control participants without diabetes receiving IV adrenaline 0.04 µg kg-1 min-1 for 1 h
- Comparison
- Adrenaline infusion in T1D vs matched controls without diabetes
- Outcome
- Inflammatory effects of adrenaline
- Follow-up
- Baseline to day 7
Methodological detailsmatched controls
- Matched controls
Main finding
As reported in the abstract
- Adrenaline acutely increased neutrophil, lymphocyte and monocyte counts in both groups
- Neutrophils and monocytes returned to baseline after 1 day; lymphocytes remained elevated for 7 days
- Monocyte function acutely shifted to a more inflammatory phenotype: increased cytokine secretion after ex vivo LPS stimulation in both groups
- Increased circulating inflammatory proteins (uPA, Flt3 ligand, CX3CL1, FGF21) after 7 days in both groups, more pronounced in T1D
Original publication
Adrenaline is a prominent driver of inflammatory responses following hypoglycaemia. Diabetologia. Published 29 January 2026. doi:10.
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