Metabolic effect of adrenaline infusion in people with type 1 diabetes and healthy individuals
Authors' conclusion
In conclusion, individuals with type 1 diabetes respond with increased lipolysis to adrenaline compared with healthy participants by mobilising the abundant NEFAs in plasma, whereas other metabolic responses were similar. This may suggest that the metabolic sensitivity to adrenaline is altered in a pathway-specific manner in type 1 diabetes.
Study context
- Population
- People with T1D and healthy individuals; CGM data from the week before the study day used to assess hypoglycaemia exposure
- Participants
- 18 vs 9
- Comparison
- Adrenaline infusion response in T1D vs healthy participants
- T1Dn = 18
- Healthyn = 9reference
- Outcome
- Metabolic response to adrenaline and whether it is modified by prior hypoglycaemia exposure
Methodological detailsthree-step ascending adrenaline infusion, hyperinsulinaemic-euglycaemic clamp
- Three-step ascending adrenaline infusion
- Hyperinsulinaemic-euglycaemic clamp
Main finding
As reported in the abstract
Metabolic response to adrenaline infusion
- Plasma NEFAs and glycerol increased only in T1D
- p<0.001
- Metabolomics: increase in the most common NEFAs
- p<0.01
Further findings
- Hypoglycaemia exposure negatively associated with NEFA response; not statistically significant
Original publication
Metabolic effect of adrenaline infusion in people with type 1 diabetes and healthy individuals. Diabetologia. Published 1 March 2024. doi:10.
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