The impact of plasma glucose decline rate on cardiac repolarisation in individuals with type 1 diabetes
Authors' conclusion
The plasma glucose decline rate has no clinically relevant effect on cardiac repolarisation, transmural dispersion or sympathoadrenal response in young, otherwise healthy men with T1D. However, individuals with dysregulated T1D may exhibit an altered threshold for sympathoadrenal activation compared to those with well-regulated diabetes.
Study context
- Population
- Young men with T1D: 10 well-regulated (HbA1c ≤53 mmol/mol), 10 dysregulated (HbA1c ≥63 mmol/mol)crossover
- Participants
- 20 men
- Comparison
- Rapid vs slow plasma glucose decline from hyperglycaemia to euglycaemia
- Primary endpoint
- Change in cardiac repolarisation (ΔQTc interval), compared between clamp days
Methodological detailsglucose clamp
- Glucose clamp
Primary result
ΔQTc interval
Mean difference
0.10 ms
95% CI −5.20 to 4.99
P = 0.970
Between Clamp-rapid and Clamp-slow
mean difference 0.10 ms (95% CI −5.20 to 4.99); P = 0.970
As reported in the abstract
- QTc interval increased from baseline after both rapid and slow glucose declines
- 5 ms
Further findings
Tpe interval and plasma adrenaline increases
- Increases in Tpe interval and plasma adrenaline comparable between clamp days
Subgroups: dysregulated vs well-regulated
- No differences in ΔQTc or ΔTpe intervals between subgroups
- After rapid decline, plasma adrenaline tended to increase more in dysregulated vs well-regulated
Original publication
The impact of plasma glucose decline rate on cardiac repolarisation in individuals with type 1 diabetes. Diabetes Obes Metab. Published 31 July 2025. doi:10.
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