Sarcopenia in type 1 diabetes mellitus: a systematic review
Authors' conclusion
Sarcopenia represents a relevant issue in T1D subjects in all age groups. Older age and lower BMI are the main determinants of muscle decline, while conflicting data are available on diabetes duration, glucose control, dietary and physical exercise behaviours. Despite these initial findings, future research should clarify the molecular basis of muscle impairment in T1D and establish accurate diagnostic procedures, preventive and therapeutic trajectories.
Study context
- Population
- T1D subjects; studies searched in PubMed-Medline and Web of Science15 studies
- Outcome
- Association between sarcopenia and T1D
Methodological detailsPRISMA guidelines, risk of bias assessed with RoB 2.0 and ROBINS-I V2
- PRISMA guidelines
- Risk of bias assessed with RoB 2.0 and ROBINS-I V2
Pooled result
As reported in the abstract
Characteristics of included studies
- Published in the last five years
- 13
- Undertaken in Europe
- 7
- Undertaken in Asia
- 6
- Cross-sectional design
- 13
- Enrolled adult T1D subjects
- 12
- Sample size of included studies (T1D subjects)
- 16 to 177
Original publication
Sarcopenia in type 1 diabetes mellitus: a systematic review. Diabetes Res Clin Pract. Published 30 July 2025. doi:10.
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