Automated insulin delivery in young children with type 1 diabetes: a systematic review and meta-analysis
An erratum to this article was published (J Clin Endocrinol Metab, 15 Jul 2026 ↗)
Pooled result · Change in TIR (70-180 mg/dL)Result — go to the resultMean change 9.88 % 95% CI 9.14–10.62Authors' conclusion
This systematic review with meta-analysis revealed that AID systems have greater benefits for improving glycemic outcomes and have good safety profiles in young children with type 1 diabetes.
Study context
- Population
- Young children (<7 years) with T1D; Web of Science, PubMed, Scopus, CENTRAL, ClinicalTrials.gov searched from inception to December 9, 2025; English only
- Participants
- 1,155 children30 studies
- Comparison
- Automated insulin delivery (AID) systems
- Outcome
- Change in TIR (70-180 mg/dL)
Methodological detailsrandom-effects models, 9 RCTs, 7 single-arm studies, 14 cohort studies
- Random-effects models
- 9 RCTs, 7 single-arm studies, 14 cohort studies
Pooled result
As reported in the abstract
Mean change
9.88 %
95% CI 9.14–10.62
P < 0.0001
AID
mean change 9.88 % (95% CI 9.14–10.62); P < 0.0001
- Equivalent to
- 2.37 hours/day
Further pooled results
Time-in-range (TIR) (70-180 mg/dL), daytime
- MC in daytime TIR
- 6.88% (95% CI 5.70 to 8.07)
TIR (70-180 mg/dL), overnight
- MC in overnight TIR
- 16.85% (95% CI 13.48 to 20.22)
TIR improvement by device
- TIR improvements were comparable across devices: MiniMed 670G
- 9.65%
- MiniMed 780G
- 10.04%
- CamAPS FX
- 10.58%
- Control-IQ
- 9.51%
- Omnipod 5
- 10.25%
- Open Source
- 6.77%
Hyperglycemia, HbA1c and hypoglycemia exposure
- AID associated with reduced hyperglycemia exposure and modest reductions in HbA1c, without significant changes in hypoglycemia exposure
Safety
- Episodes of severe hypoglycemia and DKA were infrequent
Original publication
Automated insulin delivery in young children with type 1 diabetes: a systematic review and meta-analysis. J Clin Endocrinol Metab. Published 25 March 2026. doi:10.
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