Fully automated insulin delivery systems in type 1 diabetes: A systematic review and meta‐analysis
Pooled result · TIRResult — go to the resultMD 9.99 % 95% CI 3.75%–16.22%Authors' conclusion
Fully AID systems improved glycaemic control and diabetes treatment satisfaction compared with other non-AID methods in patients with T1D, especially for younger patients. However, to achieve or exceed the desired benefits of hybrid AID, algorithm upgradation, along with the synergistic integration of multiple hormones, will be crucial for next-generation fully AID systems.
Study context
- Population
- Patients with T1D in RCTs; PubMed, Embase, Cochrane Library and Web of Science searched to 26 February 2025
- Participants
- 669 patients16 trials
- Comparison
- Fully automated insulin delivery (AID) systems vs any other insulin delivery method
- Outcome
- MD in % time blood glucose in target range (3.9-10.0 mmol/L or 4.0-10.0 mmol/L)
Methodological detailsrandom-effects models
- Random-effects models
Pooled result
TIR
MD
9.99 %
95% CI 3.75%–16.22%
P = 0.002
Fully AIDvs Control
MD 9.99 % (95% CI 3.75%–16.22%); P = 0.002
As reported in the abstract
Further pooled results
| Outcome | MD (points) (95% CI) | P value | |
|---|---|---|---|
| Diabetes treatment satisfaction | 3.70 (0.22 points to 7.18 points) | P = 0.04 | |
| −50510Difference, points (linear scale) |
Time in range (TIR) by control type (conventional insulin therapy vs hybrid AID)
- Fully AID vs conventional insulin therapy: favourable effect on TIR
- 17.44%
- Fully AID vs hybrid AID: opposite effect on TIR
- −3.05%
- Difference between subgroups
- P < 0.001
Glycaemic improvement by age and diabetes duration
- Younger patients and those with shorter diabetes duration had more significant glycaemic improvements with fully AID
Original publication
Fully automated insulin delivery systems in type 1 diabetes: A systematic review and meta‐analysis. Diabetes Obes Metab. Published 28 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →