Prevent hypoglycaemia when using automated insulin delivery systems in type 1 diabetes requires near normal glycaemic variability
Authors' conclusion
Importantly, glycaemic variability targets and ambient hyperglycaemia are interdependent. Users of automated insulin delivery need to reach a glycaemic variability of 18 % to 20 % to minimize or eradicate the risk of hypoglycaemia. Such values are those observed in healthy non-diabetic people.
Study context
- Population
- RCTs (2017–2023) in T1D comparing sensor-augmented pumps and AID systems
- Comparison
- Sensor-augmented pumps vs AID systems
- Sensor-Augmented-Pumpsn = 16 studies
- AIDn = 22 studies
- Outcome
- Glycaemic variability threshold at intercept of regression of glycaemic variability on time below range with time below range = 0%
Methodological detailsweighted linear regression
- Weighted linear regression
Pooled result
As reported in the abstract
Glycaemic variability at time below range <70 mg/dL of 0% (extrapolated)
- Time below range never reached 0%; glycaemic variability never fell below
- 28 %
Further pooled results
Glycaemic variability at time below range <54 mg/dL of 0% (extrapolated)
Original publication
Prevent hypoglycaemia when using automated insulin delivery systems in type 1 diabetes requires near normal glycaemic variability. Diabetes Metab. Published 22 November 2024. doi:10.
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