Continuous Glucose Monitoring–Derived Glycemic Phenotyping of Childhood Hypoglycemia Due to Hyperinsulinism: A Year-long Prospective Nationwide Observational Study
Authors' conclusion
This comprehensive study provides unbiased insights into glycemic frequency and long-term trends among patients with HI; such data are likely to influence and inform clinical priorities and future therapeutic trials.
Study context
- Population
- Unselected children with persistent congenital hyperinsulinism (HI); mean age 6 years, 53% with a genetic diagnosis
- Participants
- 45 children
- Outcome
- CGM-derived glycemic phenotyping, accuracy and patient experience
- Follow-up
- 12 months
Methodological detailsunselected cohort, 12 months
- Unselected cohort
- 12 months
Main finding
As reported in the abstract
Glucose levels paired with self- monitoring blood glucose (SMBG)
17 500
Mean absolute relative difference (MARD) vs SMBG
25%
Hypoglycemia detection
40%
Patients discontinuing continuous glucose monitoring (CGM), citing inaccuracy and pain
50%
Observational data: associations, not effects.
Further findings
Qualitative patient/parent feedback
- Dissatisfaction with CGM was high; feedback also positive, with improved understanding of glycemic patterns to inform behavior changes to reduce hypoglycemia
Original publication
Continuous Glucose Monitoring–Derived Glycemic Phenotyping of Childhood Hypoglycemia Due to Hyperinsulinism: A Year-long Prospective Nationwide Observational Study. J Diabetes Sci Technol. Published 20 November 2024. doi:10.
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