Risk of new‐onset type 1 diabetes in individuals with celiac disease and thyroid disease—An observational study
Authors' conclusion
The risk of developing type 1 diabetes was significantly higher for individuals with celiac disease or thyroid disease compared to those without any of these conditions. These findings support the screening of individuals with these conditions for stage 2 type 1 diabetes.
Study context
- Population
- Individuals with celiac disease, hyperthyroidism or hypothyroidism and matched controls without these conditions, real-world claims datamatched cohort
- Participants
- 47,099 / 47,099 / 164,830 / 164,830 / 980,477 / 980,477
- Exposure
- Celiac disease, hyperthyroidism or hypothyroidism vs matched controls without these conditions
- Celiac diseasen = 47,099
- Celiac controlsn = 47,099reference
- Hyperthyroidismn = 164,830
- Hyperthyroidism controlsn = 164,830reference
- Hypothyroidismn = 980,477
- Hypothyroidism controlsn = 980,477reference
- Outcome
- New-onset T1D
Methodological detailsobservational, matched-cohort, propensity score matched 1:1, real-world claims data
- Observational
- Matched-cohort
- Propensity score matched 1:1
- Real-world claims data
Main finding
As reported in the abstract
Developed T1D
Celiac disease vs Celiac controls
- Hazard ratio
- HR 2.54; P < 0.0001
Hyperthyroidism vs Hyperthyroidism controls
- Adjusted hazard ratio
- adjusted HR 2.98; P < 0.0001
Hypothyroidism vs Hypothyroidism controls
- Hazard ratio
- HR 2.41; P < 0.0001
Observational data: associations, not effects.
Further findings
T1D risk by age
- Risk was highest among individuals aged <18 years
Original publication
Risk of new‐onset type 1 diabetes in individuals with celiac disease and thyroid disease—An observational study. Diabetes Obes Metab. Published 28 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →