Uric acid and gamma‐glutamyl‐transferase in children and adolescents with obesity: Association to anthropometric measures and cardiometabolic risk markers depending on pubertal stage, sex, degree of weight loss and type of patient care: Evaluation of the adiposity patient follow‐up registry
Authors' conclusion
Abdominal obesity may trigger hyperuricemia and hepatic involvement already in prepuberty. This may be stronger in infancy than anticipated to date. Even moderate weight loss has favourable effects on cardiometabolic risk profile and glucose homeostasis.
Study context
- Population
- Children and adolescents with obesity in the Adiposity-Follow-up registry (APV); 47% boys
- Participants
- 102,936 children
- Outcome
- Correlations of BMI-SDS and WHtR with sUA, GGT and cardiometabolic markers
- Follow-up
- Baseline
Methodological detailsmulticentre registry (APV), partialized correlation analyses, follow-up analyses 3-24 months
- Multicentre registry (APV)
- Partialized correlation analyses
- Follow-up analyses 3-24 months
Main finding
As reported in the abstract
- BMI-SDS vs serum uric acid (sUA) (r; n = 26 529)
- 0.35
- BMI-SDS vs homeostasis model assessment of insulin resistance (HOMA-IR)/fasting insulin (FI) (r; n = 5513 /n = 5880)
- 0.30
- BMI-SDS vs TG/HDL-ratio (r; n = 24 501)
- 0.23
- Waist-to-height ratio (WHtR) vs sUA (r; n = 10 805)
- 0.32
- WHtR vs gamma-glutamyl-transferase (GGT) (r; n = 11 862)
- 0.34
- WHtR vs Alanine-aminotransferase (ALAT) (r; n = 11 821)
- 0.33
- WHtR vs GGT in boys (r; n = 5793)
- 0.36
- Prepubertal children (r; n = 2216)
- 0.36
- GGT and sUA vs TG/HDL-ratio, after partializing age, sex, BMI-SDS (r; n = 24 501)
- 0.27
Observational data: associations, not effects.
Further findings
Correlations after BMI-SDS reduction ≥0.2 or ≥0.5 · 3-24 months after baseline
- GGT vs TG/HDL-ratio (r; n = 1528)
- 0.22
- ΔBMI-SDS vs ΔsUA (r; n = 4160)
- 0.30
- ΔBMI-SDS vs ΔGGT (r; n = 3562)
- 0.28
- ΔWHtR vs ΔGGT (r; n = 3562)
- 0.28
- GGT most strongly related to Aspartate-aminotransferase (ASAT)/ALAT, most evident in prepuberty and with increasing weight loss
- Prepubertal children showed strongest correlations between BMI-SDS/WHtR and GGT
- All p < 0.0001
- BMI-SDS reduction ≥0.2: n = 11 096; ≥0.5: n = 3728
Original publication
Uric acid and gamma‐glutamyl‐transferase in children and adolescents with obesity: Association to anthropometric measures and cardiometabolic risk markers depending on pubertal stage, sex, degree of weight loss and type of patient care: Evaluation of the adiposity patient follow‐up registry. Pediatr Obes. Published 6 November 2022. doi:10.
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