Stage dependent alterations in PBMC mitochondrial bioenergetics in pediatric obesity: from insulin resistance to type 2 diabetes
Authors' conclusion
PBMC-based mitochondrial bioenergetic profiling suggests mitochondrial differences across different stages of IS, IR, and T2DM in pediatric obesity and may serve as a minimally invasive biomarker of early metabolic impairment.
Study context
- Population
- Children and adolescents (6–18 years) with obesity, stratified by pubertal stage and degree of insulin resistance (IR) or T2DM
- Participants
- 212 children
- Exposure
- IR vs insulin-sensitive (IS); T2D vs IS and IR, by pubertal stage
- Outcome
- PBMC mitochondrial bioenergetics (oxygen consumption rates (OCR), pmol/min/3 × 105 cells; ATP production, pmol ATP/min/3 × 105 cells)
Main finding
As reported in the abstract
- IR vs IS: P = 0.028
- IR vs IS: P = 0.028
- T2DM vs IS: P = 0.049
- T2DM vs IS: P = 0.016
- T2DM vs IS: P = 0.040
- T2DM vs IR: P = 0.002
Observational data: associations, not effects.
Original publication
Stage dependent alterations in PBMC mitochondrial bioenergetics in pediatric obesity: from insulin resistance to type 2 diabetes. Diabetes Res Clin Pract. Published 5 May 2026. doi:10.
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