Analysis of plasma extracellular vesicles in normal-weight and overweight type 2 diabetes mellitus using multimodal surface-enhanced Raman spectroscopy (SERS) and RNA-Seq
Authors' conclusion
Multimodal EV profiling identified subgroup-associated spectral and exploratory miRNA features in clinically stratified T2DM and provides a framework for studying diabetes heterogeneity, including molecular patterns associated with normal-weight diabetes.
Study context
- Population
- T2D patients stratified by BMI and race/ethnicity; plasma extracellular vesicle (EV)-enriched isolates obtained using ExoTICSERS
- Participants
- 65 patients
- Exposure
- Normal-weight vs overweight T2D in Asian and Non-Hispanic White patients
- Outcome
- EV-associated molecular features
Methodological detailsexploratory, multimodal SERS and EV-RNA sequencing
- Exploratory
- Multimodal SERS and EV-RNA sequencing
Main finding
As reported in the abstract
- SERS identified subgroup-associated spectral variation across BMI- and race/ethnicity-stratified groups
- Exploratory differential microRNA (miRNA) expression: higher miR-208a and miR-132 in A-OWD, higher miR-484 in A-NWD
- Partially overlapping EV-associated molecular features between A-NWD and W-OWD on unsupervised analyses
- Exploratory
Observational data: associations, not effects.
Original publication
Analysis of plasma extracellular vesicles in normal-weight and overweight type 2 diabetes mellitus using multimodal SERS and RNA-Seq. Diabetes Res Clin Pract. Published 15 June 2026. doi:10.
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