Efficacy and Hypoglycemia Profile of Once-weekly Insulin Icodec vs Once-daily Comparators Across Demographic Subgroups
Authors' conclusion
The efficacy and hypoglycemia profile of icodec vs OD comparators was consistent across trial populations irrespective of age, ethnicity, or race.
Study context
- Population
- Insulin-naive (ONWARDS 1, 3, 5) and insulin-experienced (ONWARDS 2, 4) adults (≥18 years) with T2D; subgroups by age (<55, 55–64, ≥65 years), ethnicity (Hispanic/Latino, non-Hispanic/Latino) and race (Asian, Black/African American, White, Other)
- Comparison
- Once-weekly insulin icodec vs once-daily basal insulin comparators
- Primary endpoint
- Change in HbA1c from baseline
- Follow-up
- Planned end of treatment
Methodological detailssubgroup analysis by age, ethnicity and race
- Subgroup analysis by age, ethnicity and race
Primary result
As reported in the abstract
Change in HbA1c across age, ethnicity and race subgroups
- Estimated treatment differences for HbA1c change similar across age, ethnicity and race subgroups; no statistically significant treatment by subgroup interactions
- Icodec vs once-daily (OD) insulin: P > 0.05 in all instances (treatment by subgroup interaction)
- Post hoc analysis
Further findings
| Outcome | P value |
|---|---|
| HbA1c <7% (<53 mmol/mol) without clinically significant or severe hypoglycemia, across subgroupsSimilar across age, ethnicity and race subgroups | P > 0.05 in all instances (treatment by subgroup interaction) |
HbA1c <7% (<53 mmol/mol) without clinically significant or severe hypoglycemia, across subgroups
- ORs similar across age, ethnicity and race subgroups
Safety
Clinically significant or severe hypoglycemic episodes
- Hypoglycemia rates numerically low for both treatment groups and consistent across age, ethnicity and race subgroups
Original publication
Efficacy and Hypoglycemia Profile of Once-weekly Insulin Icodec vs Once-daily Comparators Across Demographic Subgroups. J Clin Endocrinol Metab. Published 19 March 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →