The inflammatory proteome, obesity, and medical weight loss and regain in humans
Authors' conclusion
Broad changes in the inflammatory proteome track with changes in weight and may identify specific pathways that modify patterns of weight regain.
Study context
- Population
- Participants in a trial of medical weight-loss maintenance (60% women, 35% African American); median weight 94 kg at study entryup to 490 analysed
Methodological detailsproteomic analysis (Olink), replication in the Framingham Heart Study
- Proteomic analysis (Olink)
- Replication in the Framingham Heart Study
Primary result
As reported in the abstract
Changes in 74 inflammatory proteins with initial weight loss (≈8 kg)
Proteins changed with initial weight loss
33 of 74
Proteins increased
7
Proteins decreased
26
Further findings
Proteins associated with different rates of weight regain
- Proteins associated with rate of weight regain, some specifying chemotaxis and innate immune pathways
- 10
Prevalent obesity in the Framingham Heart Study
- Several observed protein associations also linked to prevalent obesity
Original publication
The inflammatory proteome, obesity, and medical weight loss and regain in humans. Obesity (Silver Spring). Published 5 November 2022. doi:10.
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