Unequal distribution of plasma glucagon levels among clustering-based diabetes subtypes: a Japanese cohort
Main findingResult — go to the resultAdjusted odds ratio 2.17 95% CI 1.03–4.54Authors' conclusion
The distribution of plasma glucagon levels differed among the clustering-based diabetes subtypes. SIRD is a subtype of diabetes with a hyperglucagonemic phenotype. Elucidating the reason for hyperglucagonemia in SIRD may help to clarify the mechanisms underlying the unfavorable clinical phenotype.
Study context
- Population
- Japanese participants with T1D or T2D categorized into 5 diabetes subtypes5 subtypes
- Participants
- 546 participants
- Exposure
- Plasma glucagon levels across 5 clustering-based diabetes subtypes
- Outcome
- Distribution of plasma glucagon levels among clustering-based diabetes subtypes
Main finding
As reported in the abstract
Adjusted odds ratio
2.17
95% CI 1.03–4.54
P = 0.041
By group
Severe insulin-resistant diabetes (SIRD)
45.6%
SIRD
aOR 2.17 (95% CI 1.03–4.54); P = 0.041
Observational data: associations, not effects.
Original publication
Unequal distribution of plasma glucagon levels among clustering-based diabetes subtypes: a Japanese cohort. J Clin Endocrinol Metab. Published 13 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →