Superiority of 1 h plasma glucose vs fasting plasma glucose, 2 h plasma glucose and HbA1c for the diagnosis of type 2 diabetes
Authors' conclusion
These findings support the superior utility of the IDF-recommended 1 h PG vs FPG, 2 h PG, HbA1c and FPG plus HbA1c for diagnosing type 2 diabetes.
Study context
- Population
- Participants of five independent cohorts: KoGES, CATAMERI, GENFIEV, PLIS (follow-up) and TULIP (follow-up); T2D defined by ADA or IDF criteria
- Participants
- 11,968 participants5 cohorts
- Comparison
- 1 h PG vs fasting plasma glucose (FPG) plus HbA1c for diagnosing T2D
- Outcome
- Diagnostic performance for T2D (AUC-ROC)
Methodological detailsfive independent cohorts, random-effects meta-analysis
- Five independent cohorts
- Random-effects meta-analysis
Performance
As reported in the abstract
Pooled AUC for diagnosing T2D (meta-analysis)
| Test or model | Value | AUC |
|---|---|---|
| 1 h PG | 0.97 (95% CI 0.96–0.98) | 0.97 |
| FPG plus HbA1c | 0.85 (95% CI 0.82–0.88) | 0.85 |
Value
1 h PG0.97 (95% CI 0.96–0.98)
FPG plus HbA1c0.85 (95% CI 0.82–0.88)
AUC
1 h PG0.97
FPG plus HbA1c0.85
Further findings
| Outcome | 1 h PG | FPG plus HbA1c | Δ AUC | P value |
|---|---|---|---|---|
| KoGES cohort | 0.08 | all p<0.001 | ||
| AUC | 0.96 | 0.88 | ||
| Sensitivity | 84.2 | 77.0 | ||
| Specificity | 98.6 | 87.0 | ||
| CATAMERI cohort | 0.12 | all p<0.001 | ||
| AUC | 0.98 | 0.86 | ||
| Sensitivity | 75.0 | 69.4 | ||
| Specificity | 98.4 | 78.9 | ||
| GENFIEV cohort | 0.08 | all p<0.001 | ||
| AUC | 0.97 | 0.89 | ||
| Sensitivity | 89.5 | 69.4 | ||
| Specificity | 100.0 | 88.3 | ||
| PLIS follow-up cohort | 0.22 | all p<0.001 | ||
| AUC | 0.98 | 0.76 | ||
| Sensitivity | 94.9 | 46.8 | ||
| Specificity | 100.0 | 92.3 | ||
| TULIP follow-up cohort | 0.15 | all p<0.001 | ||
| AUC | 0.98 | 0.83 | ||
| Sensitivity | 90.2 | 90.2 | ||
| Specificity | 100.0 | 65.0 |
Original publication
Superiority of 1 h plasma glucose vs fasting plasma glucose, 2 h plasma glucose and HbA1c for the diagnosis of type 2 diabetes. Diabetologia. Published 12 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →