Efficacy and hypoglycaemia outcomes of once‐weekly insulin icodec versus once‐daily basal insulin comparators across baseline HbA1c , body mass index (BMI) and duration of type 2 diabetes subgroups: A post hoc analysis of ONWARDS 1–5
Authors' conclusion
The efficacy and hypoglycaemia profile of icodec versus OD basal insulin comparators was overall consistent across trial populations irrespective of baseline HbA1c, BMI or T2D duration.
Study context
- Population
- Adults with T2D, insulin-naive (ONWARDS 1, 3 and 5) and insulin-experienced (ONWARDS 2 and 4); subgroups by baseline HbA1c (≤8%, >8% to ≤9%, >9%), BMI (<25, ≥25 to <30, ≥30 to <35, ≥35 kg/m²) and T2D duration (<5, ≥5 to <10, ≥10 to <15, ≥15 years)5 trials
- Comparison
- Once-weekly insulin icodec vs once-daily basal insulin comparators
- Primary endpoint
- Change in HbA1c from baseline
- Follow-up
- Planned end of treatment
Methodological detailssubgroup analysis, five phase 3a trials, analysed by trial
- Subgroup analysis
- Five phase 3a trials
- Analysed by trial
Primary result
As reported in the abstract
Change in HbA1c and achievement of HbA1c <7% without clinically significant or severe hypoglycaemia, across baseline HbA1c, BMI and T2D duration subgroups
- Estimated treatment differences for change in HbA1c and ORs for HbA1c <7% without clinically significant or severe hypoglycaemia, icodec vs once-daily (OD) comparators, overall consistent across baseline HbA1c, BMI and T2D duration subgroups
- No statistically significant treatment by subgroup interactions
- Post hoc analysis
Safety
- Hypoglycaemia rates numerically low for both arms and consistent across subgroups in ONWARDS 1-3 and 5
Original publication
Efficacy and hypoglycaemia outcomes of once‐weekly insulin icodec versus once‐daily basal insulin comparators across baseline HbA1c , BMI and duration of type 2 diabetes subgroups: A post hoc analysis of ONWARDS 1–5. Diabetes Obes Metab. Published 12 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →