Prediabetes remission and cardiovascular morbidity and mortality: post-hoc analyses from the Diabetes Prevention Program Outcome study and the DaQing Diabetes Prevention Outcome study
Primary result · CV death or hospitalisation for HF (DPPOS)Result — go to the resultFully adjusted HR 0.41 95% CI 0.20–0.84Authors' conclusion
Reaching prediatbetes remission is linked to a decades-long benefit, halving the risk of cardiovascular death or hospitalisation for heart failure in diverse populations. Targeting remission might represent a new approach to cardiovascular prevention.
Study context
- Population
- Participants with prediabetes in the US DPPOS and the Chinese DaQingDPOS2,402 DPPOS
- Participants
- 275 vs 2,127
- Comparison
- Prediabetes remission vs non-remission
- Remissionn = 275
- No remissionn = 2,127reference
- Primary endpoint
- CV death or hospitalisation for HF
- Follow-up
- Over 20 (DPPOS) and 30 (DaQingDPOS) years
Methodological detailsinverse probability of treatment weighting (DPPOS), meta-analysis across both data sets, DPPOS follow-up from July 31, 1996, to Feb 23, 2020
- Inverse probability of treatment weighting (DPPOS)
- Meta-analysis across both data sets
- DPPOS follow-up from July 31, 1996, to Feb 23, 2020
Primary result
CV death or hospitalisation for HF (DPPOS) · median follow-up 20 years
Fully adjusted HR
0.41
95% CI 0.20–0.84
P = 0.014
By group
Remission
1.74 per 1000 person-years
CI 0.87–3.48
No remission
4.17
CI 3.55–4.89
Remissionvs No remission
fully adjusted HR 0.41 (95% CI 0.20–0.84); P = 0.014
As reported in the abstract
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Primary endpoint in DaQingDPOS (CV death or hospitalisation for HF, 30 years)Remissionvs Non-remission | HR for CV death or hospitalisation for HF 0.49 (95% CI 0.28–0.84) | P = 0.010 | |
| CV death or hospitalisation for HF, analysed by remission reached at least once during follow-upRemissionvs Non-remission | HR for CV death or hospitalisation for HF 0.43 (CI 0.29–0.63) | P < 0.0001 | |
| 0.20.5125HR for CV death or hospitalisation for HF (log scale) |
Primary endpoint in DaQingDPOS (CV death or hospitalisation for HF, 30 years)
- Results supported by a pooled meta-analysis
Original publication
Prediabetes remission and cardiovascular morbidity and mortality: post-hoc analyses from the Diabetes Prevention Program Outcome study and the DaQing Diabetes Prevention Outcome study. Lancet Diabetes Endocrinol. Published 12 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →