Dysglycaemia and Autonomic Dysfunction: The Diabetes Prevention Program Outcomes Study
Authors' conclusion
Markers of dysglycaemia are associated with worse ECG-based autonomic dysfunction in adults with prediabetes and diabetes in the DPPOS, more so for some glycaemic markers and in women.
Study context
- Population
- Diabetes Prevention Program Outcomes Study (DPPOS) participants with ECG-based heart rate variability (HRV) at the 10-year examination; mean age 65 years, 68.2% women, 53.4% White, 43.7% prediabetes, 56.3% diabetes
- Participants
- 2,266 participants
- Exposure
- Men vs Women
- Outcome
- Associations of FPG, HbA1c, fasting insulin and HOMA-IR with cardiac autonomic function (resting HR, SDNN, rMSSD)
- Follow-up
- 10-year examination
Methodological detailssecondary analysis of DPPOS, multivariable linear regression, sex-stratified
- Secondary analysis of DPPOS
- Multivariable linear regression
- Sex-stratified
Main finding
As reported in the abstract
Glycaemic markers and cardiac autonomic function
- HbA1c and rMSSD, women (β per SD)
- −0.08 [−0.14, −0.03]
- FPG and rMSSD, women (β per SD)
- −0.08 [−0.13, −0.03]
- HbA1c and SDNN, women (β per SD)
- −0.08 [−0.12, −0.03]
- FPG and SDNN, women (β per SD)
- −0.07 [−0.11, −0.02]
- Fasting insulin and rMSSD, men
- −0.09 [−0.18, 0.00]
- HOMA-IR and rMSSD, men
- −0.11 [−0.20, −0.02]
- HOMA-IR and rMSSD, women
- −0.07 [−0.12, −0.02]
- HOMA-IR and SDNN, women only
- −0.05 [−0.10, 0.00]
Observational data: associations, not effects.
Original publication
Dysglycaemia and Autonomic Dysfunction: The Diabetes Prevention Program Outcomes Study. Diabetes Obes Metab. Published 1 September 2026. doi:10.
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