Prevention of type 2 diabetes through prediabetes remission without weight loss
Authors' conclusion
These data uncover essential pathways for prediabetes remission without weight loss
Study context
- Population
- Individuals with prediabetes in the Prediabetes Lifestyle Intervention Study (PLIS)
- Comparison
- Prediabetes remission vs no remission
Methodological detailsmulticenter, randomized, replication in the US Diabetes Prevention Program
- Multicenter
- Randomized
- Replication in the US Diabetes Prevention Program
Primary result
As reported in the abstract
- Prediabetes remission is achievable without weight loss or even with weight gain, and protects against incident T2D
- Mechanisms: improved insulin sensitivity, β-cell function and increased β-cell-GLP-1 sensitivity
- Weight gain similar in responders vs nonresponders
- Nonresponders increased visceral adipose tissue mass; responders increased subcutaneous adipose tissue
- Findings reproduced in the US Diabetes Prevention Program
- Post hoc analysis
Original publication
Prevention of type 2 diabetes through prediabetes remission without weight loss. Nat Med. Published 29 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →