Identifying subtypes of type 2 diabetes mellitus based on real-world electronic medical record data in China
Authors' conclusion
The European T2DM subtypes can be replicated in the Chinese diabetes population. The risk of CKD and DR varied among different subtypes, indicating that proper interventions can be taken to prevent specific complications in different subtypes.
Study context
- Population
- Chinese T2D patients with complete clustering data, real-world patient data cohort
- Participants
- 2,652 patients
- Exposure
- T2D subtypes vs mild age-related diabetes (MARD)
- Severe insulin-deficient diabetes (SIDD)n = 466
- Severe insulin-resistant diabetes (SIRD)n = 502
- MODn = 672
- MARDn = 1,012reference
- Outcome
- Risk of complications by T2D subtype
Methodological detailsreal-world electronic medical record data, clustering analysis
- Real-world electronic medical record data
- Clustering analysis
Main finding
As reported in the abstract
Subtype distribution and risk of CKD and DR
Hazard ratio
2.40
CI 1.16–4.96
SIRD · chronic kidney disease (CKD); higher risk with SIRD
Hazard ratio
2.16
CI 1.11–4.20
SIDD · diabetic retinopathy (DR); higher risk with SIDD
Observational data: associations, not effects.
Further findings
- Risk of stroke and coronary events had no difference among subtypes
Original publication
Identifying subtypes of type 2 diabetes mellitus based on real-world electronic medical record data in China. Diabetes Res Clin Pract. Published 26 September 2024. doi:10.
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