Assessment of 1-Hour Postload Plasma Glucose, the Metabolic Syndrome, and the Finish Diabetes Risk Score in the Prediction of Type 2 Diabetes
Authors' conclusion
By performing an OGTT in patients with IFG, an 1h-PG ≥ 155 mg/dL value may be helpful to predict T2DM at 7 years better than the use of MetS or the FINDRISC.
Study context
- Population
- Patients with impaired fasting glucose at a general hospital in Lima, Perú; mean age 56.2 ± 11.5 years, 64.0% women, 63.8% overweight/obese218 completed follow-up
- Participants
- 324 patients
- Exposure
- 1h-PG ≥155 mg/dL vs metabolic syndrome (MetS) vs Finish Diabetes Risk Score (FINDRISC) ≥13 for predicting T2D
- Outcome
- Development of T2D
- Follow-up
- 7 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
T2D prediction
| Group | Adjusted RR | AUROC |
|---|---|---|
| 1h-PG ≥ 155 mg/dL | 3.52 (95% CI 1.64-7.54) | 0.72 (0.60-0.83) |
| MetS | 1.81 (95% CI 0.96-3.38) | 0.63 (0.51-0.75) |
| FINDRISC ≥ 13 | 1.17 (95% CI 0.51-2.70) | 0.51 (0.38-0.63) |
Adjusted RR
1h-PG ≥ 155 mg/dL3.52 (95% CI 1.64-7.54)
MetS1.81 (95% CI 0.96-3.38)
FINDRISC ≥ 131.17 (95% CI 0.51-2.70)
AUROC
1h-PG ≥ 155 mg/dL0.72 (0.60-0.83)
MetS0.63 (0.51-0.75)
FINDRISC ≥ 130.51 (0.38-0.63)
- 1h-PG ≥ 155 mg/dL vs MetS: P = 0.01 — across the three AUROCs; also vs FINDRISC ≥ 13
- Developed T2D
- 21.1%
Observational data: associations, not effects.
Further findings
Exposure among those who developed T2D · 7 years
Baseline prevalence of each exposure
- Exposure among those who developed T2D — P, 1h-PG ≥ 155 mg/dL
- P < .001
- Exposure among those who developed T2D — P, MetS
- P = .013
- Exposure among those who developed T2D — P, FINDRISC ≥ 13
- P = .68
- Baseline prevalence of each exposure: 1h-PG ≥ 155 mg/dL with normal glucose tolerance
Original publication
Assessment of 1-Hour Postload Plasma Glucose, the Metabolic Syndrome, and the Finish Diabetes Risk Score in the Prediction of Type 2 Diabetes. Endocr Pract. Published 25 September 2024. doi:10.
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