One-hour post-load plasma glucose level predicts future type 2 diabetes in a community-based study of Hong Kong Chinese workforce
Authors' conclusion
High 1-hour PG identified young Chinese with 5-fold increased risk of type 2 diabetes independent of other intermediate hyperglycaemia status and clinical factors. 1-hour PG is similar to fasting and 2-hour PG in predicting type 2 diabetes.
Study context
- Population
- Hong Kong Chinese adults aged 18–55 years without diabetes who underwent 75-g oral glucose tolerance test (OGTT) in 2001–2003
- Participants
- 472 adults
- Exposure
- High 1-hour PG vs impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) in predicting T2D
- Outcome
- Progression to T2D
- Follow-up
- 12-year follow-up
Methodological detailscommunity-based, longitudinal
- Community-based
- Longitudinal
Main finding
As reported in the abstract
Developed T2D (whole cohort)
9.3%
High 1-hour PG and progression to T2D, aOR (95% CI), independent of IFG, IGT and other clinical variables
4.20
1.60, 12.40
Observational data: associations, not effects.
Further findings
Value
1-hour PG
0.84(CI 0.78–0.89)
2-hour PG
0.79(CI 0.72–0.86)
Fasting PG
0.79(CI 0.71–0.86)
- AUCs similar between 1-hour, 2-hour and fasting PG
Baseline glucose categories
- NGT with high 1-hour PG
- 23.5%
- Isolated IGT
- 10.0%
- Isolated IFG
- 4.2%
Original publication
One-hour post-load plasma glucose level predicts future type 2 diabetes in a community-based study of Hong Kong Chinese workforce. Diabetes Res Clin Pract. Published 24 May 2024. doi:10.
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