Long‐term changes in frailty and incident type 2 diabetes: A prospective cohort study based on the UK Biobank
Authors' conclusion
Long-term changes in frailty were associated with the risk of incident T2DM, irrespective of baseline frailty status. Preventing the worsening of frailty may reduce T2DM risk.
Study context
- Population
- UK Biobank participants free of baseline T2D with frailty phenotype (FP) data36,175 with follow-up assessment
- Participants
- 348,205 participants
- Exposure
- Prefrailty and frailty vs nonfrailty; long-term changes in frailty
- Outcome
- Incident T2D
Methodological detailsUK Biobank, multivariable-adjusted Cox regression
- UK Biobank
- Multivariable-adjusted Cox regression
Main finding
As reported in the abstract
Incident T2D by baseline frailty
Each group vs nonfrailtyHazard ratio (95% CI)P value
Prefrailty
1.38(1.33–1.43)
P < 0.001Frailty
1.69(1.59–1.79)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Incident T2D: prefrailty aggravationvs remained nonfrailtyGreatest risk over time | 3.03 (2.00–4.58) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Incident T2D per 1-point increase in final FP · median follow-up 5.4 years after final assessment
- T2D cases recorded
- 472
- Increased risk of T2D per 1-point increase in final FP
- 25% (95% CI 1.14-1.38; p < 0.001)
Incident T2D per 0.5-point/year increase in ΔFP
- Greater risk of T2D, independent of baseline FP
- 52% (95% CI 1.18-1.97; p < 0.001)
Sensitivity analysis using frailty index
- Using the frailty index did not materially change the results
Original publication
Long‐term changes in frailty and incident type 2 diabetes: A prospective cohort study based on the UK Biobank. Diabetes Obes Metab. Published 24 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →