Individual frailty phenotype components and mortality in adults with type 2 diabetes: A UK Biobank study
Authors' conclusion
Slow walking pace has a stronger predictive factor for all-cause and CVD mortality compared to other frailty components and overall frailty status, especially when simultaneously present with T2D.
Study context
- Population
- Adults with and without T2D, UK Biobank
- Exposure
- Individual Fried's frailty components and overall frailty status vs none, in adults with and without T2D
- Outcome
- All-cause and CVD mortality
Methodological detailsUK Biobank
- UK Biobank
Main finding
As reported in the abstract
All-cause mortality: slow walking pace (strongest association across frailty components and overall frailty status)
Hazard ratio (95 % CI)
Without T2D
2.25(2.12–2.38)
With T2D
1.95(1.67–2.28)
Observational data: associations, not effects.
Further findings
CVD mortality
- Slow walking pace was associated with a greater risk of CVD mortality
Combination of T2D and frailty components
- T2D plus slow walking pace had the strongest association with all-cause and CVD mortality vs T2D plus other frailty components or overall frailty status
Prognostic discrimination (C-index)
- Slow walking pace provided the greatest prognostic discrimination
Original publication
Individual frailty phenotype components and mortality in adults with type 2 diabetes: A UK Biobank study. Diabetes Res Clin Pract. Published 24 November 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →