Liver fat is superior to visceral and pancreatic fat as a risk biomarker of impaired glucose regulation in overweight/obese subjects
Main finding · IGRResult — go to the resultMultivariate-adjusted OR 2.842 95% CI 1.205–6.704Authors' conclusion
Compared with visceral and pancreatic fat content, LFC is a superior risk biomarker for IGR in overweight/obese subjects.
Study context
- Population
- Overweight/obese subjects with BMI ≥23 kg/m² who underwent an OGTT
- Participants
- 257 subjects
- Exposure
- Liver, pancreatic and visceral fat (MRI-proton density fat fraction) in relation to impaired glucose regulation
- Outcome
- Impaired glucose regulation (IGR): prediabetes or diabetes
Main finding
IGR
Multivariate-adjusted OR
2.842
95% CI 1.205–6.704
Highest LFC tertilevs Lowest LFC tertile
multivariate-adjusted OR 2.842 (95% CI 1.205–6.704)
As reported in the abstract
- Liver fat content (LFC) an independent risk factor of impaired glucose regulation (IGR), OR per SD unit
- 1.824 (95% CI 1.242-2.679, p = .002)
Observational data: associations, not effects.
Further findings
LFC and visceral adipose tissue (VAT) by glucose status
- LFC and VAT higher in subjects with diabetes than with normal glucose tolerance (NGT)
Prevalence of IGR by discordant visceral and liver fat phenotypes
- High LFC-low VAT and high LFC-high VAT had higher IGR prevalence than low LFC-low VAT
- No difference in IGR prevalence between low LFC-low VAT and low LFC-high VAT
Original publication
Liver fat is superior to visceral and pancreatic fat as a risk biomarker of impaired glucose regulation in overweight/obese subjects. Diabetes Obes Metab. Published 24 November 2022. doi:10.
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