Two phenotypes of metabolic cardiomyopathy: Data-driven cluster analysis of non-invasively determined cardiovascular phenotypical traits
Authors' conclusion
Two distinct types of cardiomyopathies were identified. The majority exhibited small left hearts with only moderate impairment in myocardial perfusion ratio. However, when stiff conductance arteries were present, cardiomyopathy with larger and eccentrically hypertrophic left ventricles and markedly reduced myocardial perfusion ratio was observed. Future research should seek to determine if these two phenotypes carry independent prognostic implications and should be treated differently.
Study context
- Population
- Patients with T2D
- Participants
- 192 patients
- Exposure
- Two data-driven clusters of T2D patients vs normal controls
- Outcome
- Myocardial perfusion reserve
Methodological detailsdata-driven cluster analysis, hierarchical clustering, k-means clustering
- Data-driven cluster analysis
- Hierarchical clustering
- K-means clustering
Main finding
As reported in the abstract
Small left heart
3.32
± 1.20 · ml/min/g
Normal controls
5.07
± 1.51 · ml/min/g
Eccentric hypertrophic
2.60
± 0.87 · mL/min/g
Small left heart vs Normal controls: P < 0.01 · Eccentric hypertrophic vs Small left heart; Normal controls: P < 0.01 vs. other groups
Observational data: associations, not effects.
Further findings
%
| Outcome | Small left heart | Eccentric hypertrophic |
|---|---|---|
| Cluster membership among T2D patients | 59 | 41 |
Blood pressure in Eccentric hypertrophic cluster
mmHg
- Higher mean arterial blood pressure (mean)
- 6
- Higher pulse pressure (mean)
- 15
- Equal e/e and extracellular volumes
Original publication
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