Longitudinal Metabolic Trajectories in Diabetes Prevention Program Participants Reveal Subgroups With Varying Micro- and Macrovascular Complication Risks
Authors' conclusion
Two-thirds of individuals with prediabetes follow metabolically resilient trajectories, whereas distinct insulin-resistant or renal-dysfunction trajectories precede micro- or macrovascular complications, respectively. The optimal window for macrovascular complication prevention in individuals with prediabetes microalbuminuria may precede progression to T2D.
Study context
- Population
- Diabetes Prevention Program/Outcomes Study participants with prediabetes; 12 phenotypes analysedfollow-up 19 years
- Participants
- 1,732 participants
- Comparison
- Cluster 1 vs Cluster 2 vs Cluster 3 vs Cluster 4
Methodological detailslongitudinal, tensor decomposition, Gaussian mixture modeling
- Longitudinal
- Tensor decomposition
- Gaussian mixture modeling
Primary result
As reported in the abstract
Estimate (95% CI)
Cluster 3retinopathy
OR 8.8(3.9–20.1)
Cluster 3neuropathy
OR 3.4(2.1–5.5)
Cluster 4cardiovascular events
HR 2.0(1.4–3.0)
Original publication
Longitudinal Metabolic Trajectories in Diabetes Prevention Program Participants Reveal Subgroups With Varying Micro- and Macrovascular Complication Risks. Diabetes Care. Published 26 August 2025. doi:10.
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