The relationship between plasma sphingosine-1-phosphate, plasma apolipoprotein M, obesity, and the risk of incident type 2 diabetes: a prospective cohort study
Authors' conclusion
Plasma S1P and ApoM are both associated with obesity. However, only plasma S1P is a good predictive biomarker for incident T2D, underscoring its potential for early risk assessment and intervention.
Study context
- Population
- Individuals without diabetes at baseline, Taiwan Lifestyle Study (initiated 2006); abdominal fat by CT, plasma S1P and apolipoprotein M (ApoM) by ELISA
- Participants
- 1,207 individuals
- Exposure
- Plasma S1P and ApoM levels and risk of incident T2D
- Outcome
- Incident T2D
- Follow-up
- Average 5.93 years
Main finding
As reported in the abstract
Participants who developed diabetes
152
Plasma S1P predicting diabetes, adjusted models: HR (95% CI 0.35-0.77), p = 0.001
0.52
Plasma ApoM predicting diabetes, adjusted models (not significant): HR (95% CI 0.94-1.43), p = 0.170
1.16
Observational data: associations, not effects.
Further findings
Correlation with abdominal fat
- Plasma S1P correlated with visceral, peritoneal and retroperitoneal fat
- all p < 0.001
- ApoM correlated with total, subcutaneous and visceral fat
- all p < 0.001
Predictive model incorporating S1P
- AUC
- 0.7698
- Concordance statistic
- 0.7637
- Outperformed traditional risk factors
Original publication
The relationship between plasma sphingosine-1-phosphate, plasma apolipoprotein M, obesity, and the risk of incident type 2 diabetes: a prospective cohort study. Int J Obes (Lond). Published 26 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →