Inverse relationship between circulating sphingosine-1-phosphate and precursor species and coronary artery calcification score in type 2 diabetes
Authors' conclusion
This study unraveled that circulating S1P and their precursors are biomarkers of coronary atherosclerosis in T2D, which may underlie the lower abundance of S1P and anti-inflammatory activities of HDL.
Study context
- Population
- Patients with T2D with available Coronary artery calcification (CAC) score from the DIACART and CERABIAB cohorts; 154 men and 45 women2 cohorts · DIACART 168 · CERABIAB 31 · DIACART 168 · CERABIAB 31
- Exposure
- CAC ≥100 vs CAC <100 by circulating S1P species and precursors
- Outcome
- Association of S1P species and precursors in plasma and HDL with CAC score (binary, cut-off 100)
Methodological detailstwo cohorts (DIACART and CERABIAB), LC-MS/MS quantification, in vitro experiments
- Two cohorts (DIACART and CERABIAB)
- LC-MS/MS quantification
- In vitro experiments
Main finding
As reported in the abstract
Association of S1P species/precursors with high CVD risk (CAC > 100)
- Plasma S1P levels, especially d18:1-S1P, and sphingosine in high-density lipoproteins (HDL) were inversely associated with high cardiovascular diseases (CVD) risk (CAC > 100) in T2D (multivariate analysis)
- S1P-impoverished HDL is a major feature of patients with CAC > 100 (HDL clustering)
Observational data: associations, not effects.
Further findings
In vitro anti-inflammatory properties of HDL
- Low HDL-S1P showed impaired anti-inflammatory properties vs high HDL-S1P (monocyte adhesion and inflammation in endothelial cells; macrophage inflammatory phenotype)
Original publication
Inverse relationship between circulating sphingosine-1-phosphate and precursor species and coronary artery calcification score in type 2 diabetes. Cardiovasc Diabetol. Published 21 February 2025. doi:10.
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