Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study
Authors' conclusion
This study represents the first demonstration of an independent relationship between a non-invasive liver fibrosis test and the progression of lower limb arterial calcification in patients with T2D. Beyond its utility in assessing liver fibrosis, the FibroTest® could be a valuable and easy-to-use biomarker for predicting the risk of worsening lower limb arterial calcification.
Study context
- Population
- Patients with T2D; Lower limb arterial calcification score (LLACS) by CT at baseline and after mean follow-up of 31.2 ± 3.7 months
- Participants
- 150 patients
- Outcome
- Association of MASLD biomarkers (FibroMax® panels: SteatoTest®, FibroTest®, NashTest®, ActiTest®) with annualized change in LLACS
- Follow-up
- Average 31.2 ± 3.7 months
Main finding
As reported in the abstract
Annualized change in LLACS
- Univariate correlation with baseline LLACS
- r = 0.860, p < 0.0001
- Univariate correlation with FibroTest® score
- r = 0.304, p = 0.0002
- Univariate correlation with age
- r = 0.275, p = 0.0006
- Univariate correlation with glomerular filtration rate (negative)
- r = - 0.242, p = 0.003
- FibroTest® score β, multivariate, adjusted for baseline LLACS and lower extremity artery disease risk factors
- 988, p = 0.006 (95% CI 284-1692)
- FibroTest® score β, adjusted for variables selected by principal component analysis
- 1029, p = 0.007 (CI 289-1768)
Observational data: associations, not effects.
Further findings
LLACS increased during follow-up
- Patients with increased LLACS
- 127 (85%) of 150
Original publication
Metabolic dysfunction-associated steatotic liver disease (MASLD) biomarkers and progression of lower limb arterial calcification in patients with type 2 diabetes: a prospective cohort study. Cardiovasc Diabetol. Published 23 April 2025. doi:10.
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