Epidemiology and Prognostic Implications of Coronary Artery Calcium in Asymptomatic Individuals With Prediabetes: A Multicohort Study
Authors' conclusion
CAC ≥100 is frequent among individuals with prediabetes and identifies a high ASCVD risk subgroup in which the adjusted ASCVD risk is similar to that in individuals with diabetes.
Study context
- Population
- Participants free of clinical atherosclerotic cardiovascular disease (ASCVD) from MESA, Heinz Nixdorf Recall, Framingham Heart and Jackson Heart studies; mean age 58 years, 54% women, 57% White, 27% Black
- Participants
- 13,376 participants4 cohorts
- Comparison
- Prediabetes by coronary artery calcium (CAC) category and diabetes vs euglycemia
- Outcome
- Incident ASCVD
- Follow-up
- Median 14.6 (IQR 7.8-16.4) years
Methodological detailsmulticohort, four prospective cohorts
- Multicohort
- Four prospective cohorts
Pooled result
As reported in the abstract
ASCVD, adjusted (inclusive prediabetes definition)
Each group vs euglycemiaHazard ratio (95% CI)
Prediabetes and CAC 0
0.79(0.62–1.01)
Prediabetes and CAC 1-99
0.70(0.54–0.89)
Prediabetes and CAC ≥100
1.54(1.27–1.88)
Diabetes
1.64(1.39–1.93)
Further pooled results
| Outcome | Values | HR (CI) | |
|---|---|---|---|
| ASCVD, adjusted (restrictive prediabetes definition: FPG ≥110 to <126 mg/dL)Prediabetes and CAC ≥100vs Euglycemia | 1.63 (1.29–2.06) | ||
| 0.512Hazard ratio (log scale) |
| Outcome | Values |
|---|---|
| CAC ≥100 prevalence · baseline | Euglycemia 17% · Prediabetes 22% · Diabetes 37% |
| Unadjusted 10-year ASCVD incidence | Prediabetes and CAC ≥100 13.4% · Diabetes 10.6% |
Original publication
Epidemiology and Prognostic Implications of Coronary Artery Calcium in Asymptomatic Individuals With Prediabetes: A Multicohort Study. Diabetes Care. Published 8 February 2024. doi:10.
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