Periodontitis, accelerated biological aging, and advanced stages in cardiovascular-kidney-metabolic syndrome in U.S. Adults: A mediation analysis
Authors' conclusion
These findings underscore the importance of integrating oral health into cardiometabolic care, suggesting that addressing periodontal inflammation and BAA could improve CKM outcomes.
Study context
- Population
- U.S. adults aged 30–79 years, NHANES 2009–2014
- Participants
- 3,102 adults
- Exposure
- Severe periodontitis vs none/mild
- Outcome
- CKM stage (0-4)
Methodological detailsNHANES 2009-2014, mediation analysis
- NHANES 2009-2014
- Mediation analysis
Main finding
As reported in the abstract
More advanced CKM stage (ordinal model)
Severe periodontitis vs None/mildOdds ratio (95 % CI)
Ordinal logistic regression
1.50(1.15–1.96)
Advanced CKM (stage 3-4), binary model
2.05(1.50–2.80)
- Advanced cardiovascular-Kidney-Metabolic (CKM) (stage 3-4) prevalence, all participants
- 17.8 %
Observational data: associations, not effects.
Further findings
Biological age acceleration with severe periodontitis
- KDMAge acceleration
- + 1.1 years
- Phenotypic Age (PhenoAge) acceleration
- + 1.2 years
- p < 0.001
Proportion of effect mediated by biological age acceleration (BAA)
%
- Via KDMAge
- 20.1
- Via PhenoAge
- 13.9
- p < 0.001
Original publication
Periodontitis, accelerated biological aging, and advanced stages in cardiovascular-kidney-metabolic syndrome in U.S. Adults: A mediation analysis. Diabetes Res Clin Pract. Published 25 August 2025. doi:10.
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