Prediabetes Subgroups, Type 2 Diabetes Risk, and Differential Effects of Preventive Interventions
Primary result · Diabetes riskResult — go to the resultHazard ratio 1.58 95% CI 1.31–1.91Authors' conclusion
Pathophysiologically distinct prediabetes subgroups differ in risk for diabetes and preventive benefit from metformin. These results support distinct mechanisms of diabetes susceptibility; however, the use of clinical prediction models to guide treatment decisions may provide adequate risk profiling.
Study context
- Population
- Participants with prediabetes in the Diabetes Prevention Program trial; subgroups derived from 22 clinical biomarkers (sex-standardized)
- Participants
- 3,145 participants
- Comparison
- Prediabetes subgroup 1 vs subgroup 2; intensive lifestyle or metformin vs placebo within subgroups
- Primary endpoint
- Incident diabetes by prediabetes subgroup and differential intervention effects (intensive lifestyle, metformin, placebo)
Methodological detailsK-means clustering, Cox proportional hazards regression
- K-means clustering
- Cox proportional hazards regression
Primary result
Diabetes risk
Hazard ratio
1.58
95% CI 1.31–1.91
Subgroup 1vs Subgroup 2
HR 1.58 (95% CI 1.31–1.91)
As reported in the abstract
- Metformin gave greater benefit to subgroup 1 vs subgroup 2
- P for interaction < 0.05
Further findings
Risk discrimination
- A clinical variable model discriminated diabetes risk better than the clustering strategy
Original publication
Prediabetes Subgroups, Type 2 Diabetes Risk, and Differential Effects of Preventive Interventions. J Clin Endocrinol Metab. Published 11 June 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →