The interaction of vitamin D supplementation with Omentin‐1 gene polymorphism on metabolic biomarkers, omentin‐1 levels and anthropometric measures in women with prediabetes: A double‐blind randomized controlled trial
Authors' conclusion
The findings suggest that the Omentin-1 gene Val109Asp polymorphism may modify the effects of vitamin D intervention on serum HDL-C levels and abdominal obesity in women with prediabetes. Future clinical trials are necessary to clarify the influence of the Omentin-1 gene polymorphism genotype on the effects of vitamin D intervention.
Study context
- Population
- Women aged 18–65 with prediabetes, genotyped for Omentin-1 Val109Asp polymorphism96 allocated
- Participants
- 204 women
- Comparison
- Vitamin D vs placebo, by Omentin-1 Val109Asp genotype
- Primary endpoint
- Interaction between vitamin D supplementation and Omentin-1 polymorphism on metabolic factors, omentin-1 levels and obesity values
- Follow-up
- 12 weeks
Methodological detailsdouble-blind, randomized within each Omentin-1 genotype (1:1)
- Double-blind
- Randomized within each Omentin-1 genotype (1:1)
Primary result
As reported in the abstract
Interaction of vitamin D with Omentin-1 Val109Asp polymorphism
- Significant interaction on HDL-C
- p = 0.003
- Significant interaction on waist circumference (WC)
- p = 0.026
- Significant interaction on waist-to-height ratio (WHthR)
- p = 0.035
- No significant interaction on glycaemic factors, omentin-1 levels, other lipid profiles and anthropometric measures
- p ≥ 0.05
Further findings
25(OH)D, insulin, HOMA-IR, HOMA-β and QUICKI in AT and TT genotypes
- Vitamin D significantly increased serum 25(OH)D, insulin, HOMA-IR, HOMA-β and QUICKI in both AT and TT genotypes
- all, p < 0.001
HDL-C by genotype
- HDL-C decreased significantly after vitamin D in AT genotype, but not in TT genotype
- P < 0.001
Original publication
The interaction of vitamin D supplementation with Omentin‐1 gene polymorphism on metabolic biomarkers, omentin‐1 levels and anthropometric measures in women with prediabetes: A double‐blind randomized controlled trial. Diabetes Obes Metab. Published 11 June 2025. doi:10.
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