Gestational diabetes & diabetes in pregnancy
Triglyceride glucose-body mass index and the risk of gestational diabetes mellitus: a prospective pregnancy nutrition cohort study
Main finding · GDMResult — go to the resultRelative risk 2.48Authors' conclusion
The baseline TyG-BMI in early pregnancy is a robust predictor of GDM and its subtypes. It could be integrated into early pregnancy screening to identify high-risk women before OGTT, enabling earlier interventions. Anti-inflammatory management could be explored for high-risk women with elevated TyG-BMI.
Study context
- Population
- Pregnant women from the Fujian Pregnancy Nutrition Cohort (FPNC), Southeast China
- Participants
- 1,704 women
- Exposure
- Highest vs lowest quartile of first-trimester triglyceride-glucose-body mass index (TyG-BMI)
- Outcome
- GDM
Main finding
As reported in the abstract
Relative risk
2.48
Observational data: associations, not effects.
Further findings
| Outcome | RR |
|---|---|
| IFG | 3.75 |
| IGT | 1.84 |
| IFSG | 13.00 |
Mediation by leukocytes
- Proportion of the association mediated by leukocytes
- 13.15 %
Population attributable fraction of elevated TyG-BMI
%
- Gestational diabetes mellitus (GDM) cases attributable
- 28.44
- IFSG cases attributable
- 67.29
Original publication
Triglyceride glucose-body mass index and the risk of gestational diabetes mellitus: a prospective pregnancy nutrition cohort study. Diabetes Res Clin Pract. Published 21 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →