Trends in Cystic Fibrosis–Related Diabetes Epidemiology Between 2003 and 2018 From the U.S. Cystic Fibrosis Foundation Patient Registry
Authors' conclusion
Findings support the need for the development of tailored CFRD screening algorithms and increased subspecialists to care for a growing population of adults with CF and CF-associated comorbidities.
Study context
- Population
- People with cystic fibrosis in the U.S. Cystic Fibrosis Foundation Patient Registry, 2003–2018
- Exposure
- Incident cystic fibrosis-related diabetes (CFRD) vs no CFRD; trends over time
- Outcome
- Annual screening, incidence and prevalence rates of CFRD
- Follow-up
- 2003 to 2018
Methodological detailsU.S. Cystic Fibrosis Foundation Patient Registry, 2003–2018, survival analyses, three time periods (2003-2008, 2009-2013, 2014-2018)
- U.S. Cystic Fibrosis Foundation Patient Registry
- 2003–2018
- Survival analyses
- Three time periods (2003-2008, 2009-2013, 2014-2018)
Main finding
As reported in the abstract
CFRD screening, incidence and prevalence trends
- CFRD screening rates increased from 2003 to 2018, particularly in 10- to 18-year-olds
- Screening rates increased in adults, but overall rates remained low
- Incidence of CFRD stable over time in 10- to 18-year-olds
- Incident cases in adults steadily decreased, approaching incident rates in adolescents
- Prevalence of CFRD gradually increased in adults, likely reflecting increased longevity
Observational data: associations, not effects.
Further findings
- Age, female sex, Black race, severe mutation class, liver disease, poorer lung function, pancreatic insufficiency, enteric feeds, and low and high BMI were risk factors associated with CFRD
Original publication
Trends in Cystic Fibrosis–Related Diabetes Epidemiology Between 2003 and 2018 From the U.S. Cystic Fibrosis Foundation Patient Registry. Diabetes Care. Published 15 May 2025. doi:10.
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