Transitions in Metabolic Health Status and Obesity Over Time and Risk of Diabetes: The Dongfeng–Tongji Cohort Study
Authors' conclusion
People with MHOO, even stable MHOO, or its transition to metabolically unhealthy phenotypes were at increased risk of diabetes. Metabolic improvements and weight control may reduce the risk of diabetes.
Study context
- Population
- Participants of the Dongfeng-Tongji cohort, followed 2008–2018 (median follow-up 9.9 years), categorised into 4 body mass index (BMI)-metabolic health phenotypes12,206 with 2 follow-up examinations
- Participants
- 17,309 participants
- Exposure
- Transitions in BMI-metabolic health phenotypes vs stable phenotypes
- Outcome
- Diabetes incidence
- Follow-up
- 2018
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Stable MHOOvs Stable MHNW
1.76(1.26–2.45)
MHOO to MUNWvs Stable MHNW
2.97(1.79–4.93)
MHOO to MUOOvs Stable MHNW
3.38(2.54–4.49)
MUOO to MHNWvs Stable MUOO
0.57(0.37–0.87)
MUOO to MUNWvs Stable MUOO
0.68(0.50–0.93)
MUOO to MHOOvs Stable MUOO
0.45(0.34–0.60)
Observational data: associations, not effects.
Original publication
Transitions in Metabolic Health Status and Obesity Over Time and Risk of Diabetes: The Dongfeng–Tongji Cohort Study. J Clin Endocrinol Metab. Published 31 January 2023. doi:10.
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