Physician‐led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: A randomised trial
Primary result · Mean number of medications per patient (change from baseline)Result — go to the resultRate ratio 0.81Authors' conclusion
Physician-led medication reviews and increased cross-sectoral communication in patients with type 2 diabetes treated with at least 12 medications reduced the number of medications used and improved health-related quality of life. Implementing and further investigating similar interventions as standard care seems reasonable.
Study context
- Population
- Patients with T2D treated with at least 12 medications, T2D outpatient clinic; median age 72 (IQR 67–75) years
- Participants
- 50 patients
- Comparison
- Standard care plus physician-led medication review and increased cross-sectoral communication vs standard care
- Primary endpoint
- Number of medications used
- Follow-up
- 6 months
Methodological detailspragmatic
- Pragmatic
Primary result
As reported in the abstract
Mean number of medications per patient (change from baseline)
Rate ratio
0.81
Change by group
Intervention
14.3
mean
Standard care
17.2
mean
Further findings
| Outcome | Difference (95% CI) | |
|---|---|---|
| Change in health-related quality of life (EQ5D-5 L index score)Significant difference in favour of the intervention | 0.111 (0.001–0.221) | |
| −0.100.10.20.3Difference (linear scale) |
Reasons for discontinuations
- Medication no longer indicated
- 60%
- Safety issues
- 20%
- Efficacy issues
- 15%
- Patient preferences
- 5%
Original publication
Physician‐led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: A randomised trial. Diabet Med. Published 31 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →