Outcomes of deferred revascularisation following negative fractional flow reserve in diabetic and non-diabetic patients: a meta-analysis
Authors' conclusion
For patients with stable coronary syndromes and deferred revascularisation based on FFR > 0.8, the presence of diabetes portends an increased long-term risk of MACE compared to non-diabetic patients. Trail
Study context
- Population
- Patients with revascularisation deferred based on Fractional Flow Reserve (FFR) > 0.8; studies from MEDLINE, PubMed and EMBASE
- Participants
- 4,275 patients7 studies
- Comparison
- Diabetic vs non-diabetic patients with revascularisation deferred based on negative FFR
- Diabeticn = 1,250
- Outcome
- MACE
- Follow-up
- Mean 3.2 years
Pooled result
As reported in the abstract
Diabetes associated with higher odds of MACE: OR (95% CI), p
1.66 (1.35-2.04), p = < 0.001
Further pooled results
Unplanned revascularisation
- Diabetes associated with higher odds of unplanned revascularisation: OR (95% CI), p
- 1.48 (1.06-2.06), p = 0.02
All-cause mortality
- Diabetes associated with higher odds of all-cause mortality: OR (95% CI), p
- 1.74 (1.20-2.52), p = 0.004
Cardiovascular mortality
- Diabetes associated with higher odds of cardiovascular mortality: OR (95% CI), p
- 2.08 (1.07-4.05), p = 0.03
Original publication
Outcomes of deferred revascularisation following negative fractional flow reserve in diabetic and non-diabetic patients: a meta-analysis. Cardiovasc Diabetol. Published 30 January 2023. doi:10.
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