Prognostic value of computed tomography-derived fractional flow reserve in patients with diabetes mellitus and unstable angina
Authors' conclusion
CT-FFR demonstrated significant diagnostic performance using invasive FFR as the reference standard and proved to be an important predictive tool for assessing prognosis not only in calcified lesions but also in lesions with a CACS score of zero in patients with T2DM and UA. CT-FFR may serve as a valuable tool for guiding treatment decisions in these patients.
Study context
- Population
- Patients with T2D and unstable angina who underwent coronary computed tomography angiography (CTA) with at least one visible calcification site; subset completed invasive coronary angiography and invasive fractional flow reserve (FFR)1,091 with invasive FFR
- Participants
- 3,392 patients
- Exposure
- CT-FFR ≤ 0.80 vs CT-FFR > 0.80
- Outcome
- Diagnostic performance of CT-FFR vs invasive FFR (per patient)
Main finding
As reported in the abstract
| Group | Accuracy | Sensitivity | Specificity | PPV | NPV | AUC |
|---|---|---|---|---|---|---|
| CT-FFR | 84.8% | 84.6% | 85.1% | 84.7% | 85.0% | 84.8% |
CT-FFR
Accuracy84.8%
Sensitivity84.6%
Specificity85.1%
PPV84.7%
NPV85.0%
AUC84.8%
Observational data: associations, not effects.
Further findings
Lesion and calcification characteristics
- Degree of stenosis, lesion length, rate of bifurcation lesions, diffuse lesions, occlusion, calcium volume and coronary artery calcification score (CACS) significantly higher with CT-FFR ≤ 0.8 vs CT-FFR > 0.8
- Minimum cross-sectional area smaller with CT-FFR ≤ 0.8 vs CT-FFR > 0.8
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Prognostic value of computed tomography-derived fractional flow reserve in patients with diabetes mellitus and unstable angina. Cardiovasc Diabetol. Published 8 November 2024. doi:10.
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