Frequency of prediabetes in individuals with increased adiposity and metabolically healthy or unhealthy phenotypes
Authors' conclusion
A metabolically healthy phenotype is associated with lower frequency of IFG, IGT, and IFG + IGT status across all body weight categories.
Study context
- Population
- Non-diabetic individuals stratified into quartiles of insulin sensitivity by estimated glucose disposal rate (eGDR) index (waist circumference, hypertension, HbA1c) and by BMI
- Participants
- 2,201 individuals
- Exposure
- Metabolically healthy vs metabolically unhealthy phenotypes across BMI categories
- Outcome
- Prevalence of prediabetic conditions (IFG, IGT, IFG + IGT)
Main finding
As reported in the abstract
Frequency of IFG, IGT and IFG + IGT
- Frequency of impaired fasting glucose (IFG), impaired glucose tolerance (IGT) and IFG + IGT comparable among metabolically healthy normal weight (MHNW), metabolically healthy overweight (MHOW) and metabolically healthy obesity (MHO)
- Frequency increased from metabolically unhealthy normal weight (MUNW) towards metabolically unhealthy overweight (MUOW) and metabolically unhealthy obesity (MUO)
- Vs MHNW, OR of IFG, IGT or IFG + IGT significantly higher in MUOW and MUO but not in MUNW, MHOW and MHO
Observational data: associations, not effects.
Original publication
Frequency of prediabetes in individuals with increased adiposity and metabolically healthy or unhealthy phenotypes. Diabetes Obes Metab. Published 8 May 2024. doi:10.
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