Prediabetes, participation in the English National Health Service Diabetes Prevention Programme, and associations with COVID-19-related mortality: A whole population study
Main finding · COVID-19-related mortalityResult — go to the resultAdjusted hazard ratio 0.95 CI 0.93–0.96Authors' conclusion
Younger people with diagnosed NDH were at higher relative risk of COVID-19 mortality. Attendance at the NHS DPP was associated with significantly lower COVID-19-related mortality.
Study context
- Population
- All individuals registered with General Practices in England and alive on 1st March 2020
- Participants
- 61,438,225 individuals
- Exposure
- Diagnosed non-diabetic hyperglycaemia (NDH) vs no diagnosed NDH or diabetes
- NDHn = 2,290,280
- Outcome
- COVID-19-related mortality
- Follow-up
- March 2020 to February 2022
Methodological detailsCox regression adjusted for demographic factors and cardiovascular comorbidities, stratified by age
- Cox regression adjusted for demographic factors and cardiovascular comorbidities
- Stratified by age
Main finding
As reported in the abstract
Adjusted hazard ratio
0.95
CI 0.93–0.96
P < 0.001
Events by group
NDH
11 %
17,280
NDHvs No NDH or diabetes
adjusted HR 0.95 (CI 0.93–0.96); P < 0.001
Observational data: associations, not effects.
Further findings
| Outcome | HR (CI) | P value | |
|---|---|---|---|
| COVID-19 mortality, age <50 years | 2.53 (2.23–2.88) | P < 0.001 | |
| COVID-19 mortality, age 50-69 years | 1.29 (1.24–1.35) | P < 0.001 | |
| COVID-19 mortality, age ≥ 70 years | 0.87 (0.85–0.89) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
NHS DPP attendance (N = 376,590 with DPP contact)
- NHS DPP attendance associated with lower COVID-19 mortality, with a dose-response relationship with engagement
Original publication
Prediabetes, participation in the English National Health Service Diabetes Prevention Programme, and associations with COVID-19-related mortality: A whole population study. Diabetes Res Clin Pract. Published 7 May 2024. doi:10.
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